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Can HHD lesions appear in the mouth or vulva?

Epithelial cells cover - or line - all surfaces of the body. Epithelial cells are divided into subgroups that include:

• Epidermal cells - covering the skin
• Mucosal cells - that cover the surface of the mouth, vulva, oesophagus and conjunctiva (basically the 'wet' bits).

We know that HHD lesions can appear on the skin - but can they also appear in other epithelial cell types?

From the scientific literature it would seem that mucosal involvement is rare, but has been reported in the mouth, vulva, esophagus and conjunctiva. A list of references reporting these outbreaks are listed below in case you want to read more.

References

Botvinick I. Familial benign pemphigus with oral mucous membrane lesions. Utis (1973) 12:371-373.

Kahn D & Hutchinson, E. Esophageal involvement in familial benign chronic pemphigous. Archives of Dermatology (1974) 109:718-719.

Heinze R. Pemphigous chronicus benignos familiaris (Goujerot-Hailey-Hailey) with affection of mucous membranes. Dermatol. Monatsschr (1979) 165:82-867

Evron S, Leviation A & Okon E. Familial benign chronic pemphigus appearing as leukoplakia of the vulva. International Journal of Dermatology (1984) 23:556-557

Thanks to Rebecca for providing this information. April 2002.

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